The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System

The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System

Aging is the most vital danger issue for the onset of a number of power illnesses and practical decline. Understanding the interplays between organic getting older and the biology of illnesses and practical loss in addition to integrating a function-centered strategy to the care pathway of older adults are essential steps in the direction of the elaboration of preventive methods (each pharmacological and non-pharmacological) towards the onset and severity of burdensome power situations throughout getting older. In order to sort out these two essential challenges

how each the manipulation of organic getting older and the implementation of a function-centered care pathway (the Integrated Care for Older People (ICOPE) mannequin of the World Health Organization) might contribute to the trajectories of wholesome getting older, a brand new initiative on Gerosciences was constructed: the INSPIRE analysis program. The current article describes the scientific background on which the foundations of the INSPIRE program have been constructed and supplies the basic strains of this initiative that includes researchers from primary and translational science, scientific gerontology, geriatrics and major care, and public well being.

In the poor chewing capacity group, all nutrient consumption ranges have been considerably low, besides for carbohydrates, and consumption ranges for all meals teams have been considerably low, besides for cereals, confectionery, sugars, seasonings, and spices. Additionally, after adjusting for covariates for intercourse, age, Tokyo Metropolitan Institute of Gerontology-Index of Competence (TMIG-IC) rating, Mini-Mental State Examination (MMSE) rating, physique mass index (BMI), stroke, variety of practical enamel, power consumption, and protein consumption, chewing capacity was discovered to be considerably related to undernutrition.

[Regional System of Integrated Health and Social Care for Elderly People: Experience and Expertise of Saint-Petersburg]

 

The article examines the challenges of making a system of built-in well being and social care for aged folks (the System) in Russia, these challenges being of specific significance in the mild of the unfavorable results of the COVID-19 pandemic on the high quality of life and psychological and basic well being of aged folks, which want to be mitigated with due consideration of the dynamics of development of age-associated power illnesses of aged folks. The article describes the construction of the System, and the situations and background of its institution. It additionally appears to be like at the elements of system-based assist of enchancment of high quality of lifetime of aged folks.

The article argues that it’s important to use the constructive and unfavorable experiences of various areas, to implement the sensible and scientific experience in the discipline of gerontology and geriatrics made up to now in Russia, and to set up a significant and equal partnership amongst the state, analysis organizations, communities of execs and personal organizations. The authors counsel to look on Saint-Petersburg as a mannequin area when establishing the System.

The article accommodates a listing of the main initiatives and occasions in the metropolis from 2012 to 2020 aimed to present system-based assist for built-in well being and social care for aged folks, not affiliated with any federal packages. Unbiased analysis of the expertise and experience of Saint-Petersburg and different areas of Russia will enable to use them when establishing comparable methods in different Russia’s areas that don’t possess adequate sources. The authors counsel to set up the System in a step-wise method at the federal district stage. For instance, a pilot mission could also be launched in the North-Western Federal District utilizing the expertise and experience of Saint-Petersburg.

The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System

Innovations in Geroscience to improve mobility in older adults

 

Aging is the major danger issue for practical decline; thus, understanding and stopping incapacity amongst older adults has emerged as an vital public well being problem of the 21st century. The science of gerontology – or geroscience – has the sensible function of “including life to the years.” The total objective of geroscience is to improve healthspan, which refers to extending the portion of the lifespan during which the particular person experiences enjoyment, satisfaction, and wellness. An vital aspect of this objective is preserving mobility, outlined as the capacity to transfer independently.

Despite this clear function, this has confirmed to be a difficult endeavor as mobility and perform in later life are influenced by a posh interplay of things throughout a number of domains. Moreover, findings over the previous decade have highlighted the complexity of strolling and how focusing on a number of methods, together with the mind and sensory organs, in addition to the setting during which an individual lives, can have a dramatic impact on an older particular person’s mobility and perform.

For these causes, behavioral interventions that incorporate advanced strolling duties and different actions of every day dwelling seem to be particularly useful for enhancing mobility perform. Other pharmaceutical interventions, comparable to oxytocin, and complementary and various interventions, comparable to therapeutic massage remedy, might improve bodily perform each via direct results on organic mechanisms associated to mobility, in addition to not directly via modulation of cognitive and socioemotional processes.

Protein-A,-434 Staphylococcal Protein A 434 a.a Recombinant Protein

PROTP38507-1 Regular: 50ug
EUR 317
Description: Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain containing 434 amino acids (37-469 a.a.) and having a molecular mass of 48.1 kDa. Recombinant Staphylococcal Protein A is purified by proprietary chromatographic techniques.

Staphylococcal Protein A 434 a.a Protein

20-abx260631
  • EUR 230.00
  • EUR 3042.00
  • EUR 328.00
  • 10 ug
  • 1 mg
  • 50 ug
  • Shipped within 5-10 working days.

Recombinant Staphylococcal Protein-A

7-06496 10mg Ask for price

Recombinant Staphylococcal Protein-A

7-06497 100mg Ask for price

Recombinant Staphylococcal Protein-A

7-06498 1gram Ask for price

Protein-A Staphylococcal Protein A Recombinant Protein

PROTP38507 Regular: 100mg
EUR 524
Description: Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain having a molecular mass of 45 kDa.;Recombinant Staphylococcal Protein A is purified by proprietary chromatographic techniques.

Recombinant Staphylococcal Protein-A 41kDa

7-06499 10mg Ask for price

Recombinant Staphylococcal Protein-A 41kDa

7-06500 100mg Ask for price

Recombinant Staphylococcal Protein-A 41kDa

7-06501 1gram Ask for price

Recombinant Staphylococcal Protein A (SPA)

4-RPA169Ge02
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Inquire
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 33kDa
  • Isoelectric Point: Inquire
Description: Recombinant Pan-species Staphylococcal Protein A expressed in: E.coli

Recombinant (E.Coli) Staphylococcal Protein-A

RP-816 5 mg
EUR 164

Staphylococcal enterotoxins A

AT043 1mg
EUR 945

Staphylococcal enterotoxins A

AG043 1 mg
EUR 523

Protein-A,-41kDa Staphylococcal Protein A 41kDa Recombinant Protein

PROTP38507-2 Regular: 100mg
EUR 524
Description: Recombinant Staphylococcal Protein A produced in E.Coli is a non-glycosylated, Polypeptide chain contaning the amino acid sequence of Staphylococcal Protein A IgG binding domains having a molecular mass of 41 kDa. The recombinant Protein A contains 6 IgG-binding regions of protein A. Cell wall binding region, albumin binding region and other non-specific binding regions that have been eliminated from the recombinant Protein-A to ensure the maximum specific IgG binding._x000D_ Recombinant Staphylococcal Protein A is purified by proprietary chromatographic techniques._x000D_

SPA Staphylococcal Protein-A 33.4kDa Recombinant Protein

PROTP38507-3 Regular: 100mg
EUR 418
Description: SPA Recombinant produced in E.Coli is a homodimeric non-glycosylated polypeptide chains comprised of 5 IgG-binding domains E-D-A-B-C aligned in series containing 296 amino acids and having a molecular mass of 33.4kDa containing little or no carbohydrate. Cell wall binding region, cell membrane binding region and albumin binding region were removed to ensure the highest specific IgG binding.

Staphylococcal Protein-A Cys Protein

20-abx260059
  • EUR 467.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Cys Protein

abx260059-1gr 1 gr
EUR 1970
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Cys Protein

20-abx260060
  • EUR 467.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Cys Protein

abx260060-1gr 1 gr
EUR 1970
  • Shipped within 5-10 working days.

SPA-Cys Staphylococcal Protein-A Cys Recombinant Protein

PROTP38507-4 Regular: 100mg
EUR 418
Description: SPA-Cys Recombinant produced in E.Coli is a single non-glycosylated polypeptide chain with a Cys on C-terminus. SPA-Cys is comprised of 5 IgG-binding domains E-D-A-B-C aligned in series containing 297 amino acids and having a molecular mass of 33.5kDa containing little or no carbohydrate. Cell wall binding region, cell membrane binding region and albumin binding region were removed to ensure the highest specific IgG binding.

SPA Staphylococcal Protein-A Long Form Recombinant Protein

PROTP38507-8 Regular: 100mg
EUR 418
Description: SPA Recombinant Long Form produced in E.Coli is a single non-glycosylated polypeptide chain. SPA Long Form is comprised of 5 IgG-binding domains E-D-A-B-C aligned in series containing 422 amino acids (including a.a 273-400 from acc# P99134) and having a molecular mass of 46.6kDa containing little or no carbohydrate.

Staphylococcal Protein-A 33.4 kDa Protein

20-abx260058
  • EUR 467.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A 33.4 kDa Protein

abx260058-1gr 1 gr
EUR 1970
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Long Form Protein

20-abx260063
  • EUR 467.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Long Form Protein

abx260063-1gr 1 gr
EUR 1970
  • Shipped within 5-10 working days.

Staphylococcal Protein-A 41 kDa Protein

20-abx260078
  • EUR 592.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A 41 kDa Protein

abx260078-1gr 1 gr
EUR 1845
  • Shipped within 5-10 working days.

Staphylococcal Protein A (SPA) Antibody (HRP)

20-abx274225
  • EUR 467.00
  • EUR 244.00
  • EUR 1386.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Staphylococcal Protein-A Cys Long Form Protein

20-abx260061
  • EUR 467.00
  • EUR 217.00
  • 100 mg
  • 10 mg
  • Shipped within 5-10 working days.

Staphylococcal Protein-A Cys Long Form Protein

abx260061-1gr 1 gr
EUR 1970
  • Shipped within 5-10 working days.

SPA-Cys Staphylococcal Protein-A Cys Long Form Recombinant Protein

PROTP38507-6 Regular: 100mg
EUR 418
Description: SPA-Cys long Recombinant produced in E.Coli is a single non-glycosylated polypeptide chain with a Cys on C-terminus. SPA-Cys is comprised of 5 IgG-binding domains E-D-A-B-C aligned in series containing 423 amino acids and having a molecular mass of 46.7kDa containing little or no carbohydrate.

Human staphylococcal protein A?SPA ELISA Kit

201-12-2145 96 tests
EUR 440
  • This staphylococcal protein A?SPA ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Chicken Anti-Staphylococcal Protein A Polyclonal Antibody

DPAB0288 1 mg
EUR 611

Rat staphylococcal protein A(SPA)ELISA Kit

QY-E10477 96T
EUR 361

Mouse staphylococcal protein A(SPA)ELISA Kit

QY-E21396 96T
EUR 361

Mouse pre-microRNA Expression Construct mir-434

MMIR-434-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Human Staphylococcal Protein A (S. aureus Protein A) ELISA Kit

abx053285-96tests 96 tests
EUR 668
  • Shipped within 5-10 working days.

NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Medium (6X1mL)

NATCT(434)-ERCM 6X1mL
EUR 401.52
  • What is the product classification?
  • NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Medium is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

IFNG a.a. Interferon-gamma 139 a.a Human Recombinant Protein

PROTP01579-2 Regular: 10ug
EUR 317
Description: IFNG 139 a.a. Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (24-161 a.a.) and having a molecular mass of 16.3kDa.; IFNG 139 a.a. is purified by proprietary chromatographic techniques.

NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Low (6 X 1 mL)

NATCT(434)-ERCL 6 X 1 mL
EUR 339.12
  • What is the product classification?
  • NATtrol Chlamydia trachomatis LGV II 434, External Run Control, Low is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

FCER1A 201 a.a IgE Receptor Subunit A Human Recombinant Protein

PROTP12319-1 Regular: 50ug
EUR 317
Description: FCER1A Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 201 amino acids.;FCER1Ais fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

SILAC-IMDM

434 500 ml
EUR 99

Rabbit Anti-MERS Spike protein (1-1297 a.a) IgG, aff pure

MERS121-A 100 ul
EUR 482

IL36A a.a. Interleukin-36 Alpha 153 a.a Mouse Recombinant Protein

PROTQ9JLA2-1 Regular: 10ug
EUR 317
Description: IL36A 153 a.a. Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (8-160a.a.) and having a molecular mass of 17.0kDa.;The IL36A 153 a.a. Mouse is purified by proprietary chromatographic techniques.

IL36B a.a. Interleukin-36 Beta 153 a.a Human Recombinant Protein

PROTQ9NZH7-1 Regular: 10ug
EUR 317
Description: IL36B 153 a.a. Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (5-157a.a.) and having a molecular mass of 17.2kDa.;The IL36B 153 a.a. Human is purified by proprietary chromatographic techniques.

IL36G a.a. Interleukin-36 Gamma (152 a.a) Human Recombinant Protein

PROTQ9NZH8-1 Regular: 10ug
EUR 317
Description: IL36G (152 a.a.) Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 152 amino acids and having a molecular mass of 17.0kDa.;The IL36G (152 a.a.) is purified by proprietary chromatographic techniques.

Phosphatase 1G 546 a.a. Protein (Recombinant)

20-abx073716
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Omentin 298 a.a. Human Recombinant Protein

PROTQ8WWA0 Regular: 20ug
EUR 317
Description: Omentin Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (17-313) and having a molecular mass of 33.2 kDa.;The Omentin is purified by proprietary chromatographic techniques.

Rabbit Anti-MERS-CoV Spike protein S2 (726-1296 a.a) IgG, aff pure

MERSS22-A 100 ul
EUR 482

Staphylococcal enterotoxin B

AT119 1mg
EUR 1114

Staphylococcal enterotoxin C

AT120 1mg
EUR 1114

Staphylococcal enterotoxin D

AT121 1mg
EUR 1114

Staphylococcal enterotoxin E

AT122 1mg
EUR 945

Staphylococcal enterotoxin B

AG119 1 mg
EUR 438

Staphylococcal enterotoxin C

AG120 1 mg
EUR 438

Staphylococcal enterotoxin D

AG121 1 mg
EUR 438

Staphylococcal enterotoxin E

AG122 1 mg
EUR 438

GLU-C S.aureus Glutamyl endopeptidase Staphylococcal Recombinant Protein

PROTP0C1U8 Regular: 250ug
EUR 317
Description: Recombinant Staphylococcal GLU-C produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 267 amino acids and having a molecular mass of 28.9kDa.

Recombinant Staphylococcal Nuclease Domain Containing Protein 1 (SND1)

4-RPF285Hu01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Inquire
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 28.5kDa
  • Isoelectric Point: 5
Description: Recombinant Human Staphylococcal Nuclease Domain Containing Protein 1 expressed in: E.coli

a.a.), TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant Protein, Active

PROTP50591-2 Regular: 10ug
EUR 317
Description: Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids _x000D_ (114-281) and having a molecular mass of 19.6 kDa._x000D_ The sTRAIL is purified by proprietary chromatographic techniques.

Recombinant (E.Coli, His-tag) Cell Division Cycle 34 (CDC34)

RP-434 10 ug
EUR 225

Recombinant Salmonella Protein (aa 1-434)

VAng-Wyb0582-inquire inquire Ask for price
Description: Salmonella typhi Vi polysaccharide export inner-membrane protein vexD, recombinant protein.

Recombinant Human Omentin 298 a.a.

7-01318 5µg Ask for price

Recombinant Human Omentin 298 a.a.

7-01319 20µg Ask for price

Recombinant Human Omentin 298 a.a.

7-01320 1mg Ask for price

Recombinant Human Protein Phosphatase 1G 546 a.a.

7-03433 2µg Ask for price

Recombinant Human Protein Phosphatase 1G 546 a.a.

7-03434 10µg Ask for price

Recombinant Human Protein Phosphatase 1G 546 a.a.

7-03435 1mg Ask for price

Recombinant Human BD-1 (36 a.a.) Protein

PROTP60022-1 20ug
EUR 317
Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-1 is a 3.9 kDa protein containing 36 amino acid residues.

Recombinant Human IL-16 (121 a.a.) Protein

PROTQ14005-3 10ug
EUR 317
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.3 kDa protein consisting of 129 amino acid residues.

Recombinant Human IL-16 (129 a.a.) Protein

PROTQ14005-4 10ug
EUR 317
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.

Recombinant Human MDC (67 a.a.) (CCL22) Protein

PROTO00626-2 20ug
EUR 317
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Recombinant Human MDC (69 a.a.) (CCL22) Protein

PROTO00626-3 20ug
EUR 317
Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity. Recombinant human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Recombinant Human FGF-basic (146 a.a.) Protein

PROTP09038-5 50ug
EUR 317
Description: FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic (146 a.a.) is a 16.4 kDa protein consisting of 146 amino acid residues.

Recombinant Human FGF-basic (154 a.a.) Protein

PROTP09038-6 50ug
EUR 317
Description: FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.

Recombinant Human Oncostatin-M (209 a.a.) Protein

PROTP13725-5 10ug
EUR 317
Description: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activate T cells, monocytes and Kaposi’s sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide and generates the mature OSM form. Recombinant human Oncostatin M is a 23.6 kDa protein, containing 209 amino acid residues.

Recombinant Human Oncostatin M (227 a.a.) Protein

PROTP13725-6 10ug
EUR 317
Description: Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues.

Recombinant Rat IL-13 (109 a.a.) Protein

PROTP42203-2 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.

Recombinant Rat IL-13 (113 a.a.) Protein

PROTP42203-3 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.

Rabbit Anti-MERS-CoV Nucleoprotein/NP (1-413 a.a) IgG, , aff pure

MERSNP12-A 100 ul
EUR 482

ITLN1 298 a.a. Protein

20-abx260698
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

HIF1a (85 a.a.) Protein

20-abx263442
  • EUR 230.00
  • EUR 1609.00
  • EUR 328.00
  • 1 µg
  • 50 ug
  • 5 ug
  • Shipped within 5-10 working days.

IL16 (121 a.a.) Protein

20-abx262189
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL13 109 a.a. Protein

20-abx262191
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL16 (130 a.a.) Protein

20-abx262202
  • EUR 328.00
  • EUR 5826.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL36G 152 a.a. Protein

20-abx262383
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL36A 158 a.a. Protein

20-abx262384
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL36B 153 a.a. Protein

20-abx262385
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

IL36A 153 a.a. Protein

20-abx262386
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Staphylococcal Alpha – Toxin P1

5-01961 4 x 5mg Ask for price

Recombinant Human Oncostatin-M (209 a.a.)

7-01333 2µg Ask for price

Recombinant Human Oncostatin-M (209 a.a.)

7-01334 10µg Ask for price

Recombinant Human Oncostatin-M (209 a.a.)

7-01335 1mg Ask for price

IL-8 (77 a.a.), human recombinant

4149-1000
EUR 3965

IL-8 (77 a.a.), human recombinant

4149-25
EUR 283

IL-8 (72 a.a.), human recombinant

4149M-1000
EUR 3965

IL-8 (72 a.a.), human recombinant

4149M-25
EUR 283

Thus, the function of the current overview is to describe evolving interventional approaches to improve mobility and keep healthspan in the rising inhabitants of older adults in the United States and nations all through the world. Such interventions are probably to be significantly assisted by technological advances and the widespread adoption of digital communications throughout and after the COVID-19 period.